This framework outlines how to integrate gender equality and social inclusion (GESI) into ADB's operations in South Asia to help close the gender gap, combat exclusion, and bolster equitable economic growth. It highlights the experience of women and disadvantaged groups and assesses the impact of pervasive gender inequality and social exclusion. It includes practical guides and tools that can be integrated throughout project design and implementation. It underscores the need to improve data collection showing how women and vulnerable groups are excluded and increase financial and technical support to better target inclusive and sustainable development.