A framework to implement the One Health approach at the national level may facilitate its implementation and assist national authorities in addressing the agenda of (i) enhancing national capacity for zoonotic diseases and AMR for prevention, detection and response; and (ii) improving joint coordination and collaboration between major stakeholders for control of zoonoses and AMR.With this objective, FAO has developed a National Framework for One Health to assist national authorities in initiating steps to strengthen efforts towards the control of AMR and disease in a comprehensive manner through collaborative activities among various sectors. The framework has been developed through extensive consultations with leading scientists from human health, animal health, fisheries, environment sectors representing research and academic institutions and international agencies.