Table of Contents Chapter 1 - Overview of Blood and Hematopoietic Tissues (Aster and Bunn) Impact of blood in health and disease Red blood cell White blood cells Platelets Blood clotting proteins The bone marrow The spleen The thymus Lymph nodes Chapter 2 - Hematopoiesis and the Bone Marrow (Scadden) Hematopoietic cell diffrerentiation Myeloid lineage Erythroid lineage Megakaryocyte-platelet lineage Lymphoid lineages - B, T, and NK cells The biology of the stem cell Self-renewal Stem cell ontogeny Stem cell trafficking The regulation of blood cell formation The bone marrow niche and cell-cell interactions Cytokines in early hematopoietic differentiation Lineage specific cytokines Cytokine therapy Stem cell therapy Section I - Anemias and Disorders of the Red Blood Cell Chapter 3 - Overview of the Anemias (Bunn) (See full sample chapter) Definition of anemia Adaptations to anemia Alterations in blood flow Changes in oxygen unloading Stimulation of erythropoiesis Signs and symptoms of anemia Pathophysiology of anemia Anemia due to blood loss Anemia due to decreased red cell production Microcytic Macrocytic Normocytic Anemia due to increased red cell destruction Chapter 4 - Anemias due to Bone Marrow Failure or Infiltration (Bunn) Congenital causes of bone marrow failure Acquired aplastic anemia and pure red cell aplasia Myelophthisis Myelodysplasia Leukemias (Myelodysplasia and the leukemias will be covered in detail in Chapters 21 and 22). Chapter 5 - Iron Homeostasis: Deficiency and Overload (Heeney) Normal iron homeostasis Iron binding proteins: transferrin; ferritin The iron cycle Role of hepcidin in iron regulation Iron utilization in erythropoiesis Laboratory evaluation of iron status Serum iron and transferrin saturation Serum ferritin Bone marrow and liver iron stores Serum transferrin receptor Iron deficiency Etiology Clinical features - signs and symptoms Hematological features Treatment Iron overload Primary - inherited mutations in proteins regulating iron homeostasis Secondary - transfusional hemosiderosis Chapter 6 - Mega.