Ex-convict Paul Little has just walked out on the only woman who has ever loved him to return to a life of crime in Philadelphia. But when Paul gets involved with a petty thug who is later murdered, he finds himself pinned between the volatile gangster accused of the crime and the straight-laced detective who put Paul away years ago. Realizing the city may be the death of him, Paul looks to escape to North Carolina and live alone on a farm left to him by his recently deceased grandfather. Can Paul survive long enough to make it to the succor of the farm? Will he inevitably return to a life behind bars? Or is it his fate to die a victim in Philadelphia? The Science of Paul is a stunning tale of redemption and self-exploration, as one man navigates the precariousness of the streets and the inner workings of his mind.