About the Book Keep Your Course Current and Relevant Two new Special Topics in Modern Genetics mini-chapters explore cutting-edge topics, including CRISPR-Cas and Genomic Editing and Advances in Neurogenetics: The Study of Huntington Disease . All Special Topics chapters include a series of questions that help students review key ideas or facilitate personal contemplations and group discussions. Assessment questions for Special Topics in Modern Genetics Chapters are assignable in Mastering Genetics. Reorganized and expanded coverage of gene regulation in eukaryotes reflects recent discoveries that reveal RNA in many forms play critical roles in the regulation of eukaryotic gene activity. A single chapter on this topic in previous editions has been expanded to three: Transcriptional Regulation in Eukaryotes (Chapter 17), Posttranscriptional Regulation in Eukaryotes (Chapter 18), and Epigenetics (Chapter 19). An increased emphasis on ethical considerations helps students think through ethical aspects of genetics-related issues. Essays that used to be known as Genetics, Technology, and Society have been replaced or revised as Genetics, Ethics, and Society . In addition, each chapter ends with a Case Study, each of which raises ethical questions.

Motivate Students to Develop and Practice Problem-solving Skills Updated! Mastering Genetics is an online homework and assessment program that guides students through complex topics in genetics, using in-depth tutorials that coach students to correct answers with hints and feedback specific to their misconceptions and errors. See "Personalize Learning with Mastering Genetics." Engage Students in Active and Cooperative Learning Genetics, Ethics, and Society essays provide a synopsis of an ethical issue related to a current finding in genetics that impacts directly on society today. It includes a section called Your Turn , which directs students to related resources of short readings and websites to support deeper investigation and discussion of the main topic of each essay. Case studies at the end of each chapter have been updated with new topics. Students can read and answer questions about a short scenario related to one of the chapter topics. The Case Studies link the coverage of formal genetic knowledge to everyday societal issues, and they include ethical considerations. Chapter Content Updates: Chapter 1: Introduction to Genetics New introductory vignette that discusses the discovery and applications of the genome-editing CRISPR-Cas system Updated section called: We Live in the Age of Genetics Chapter 5: Sex Determination and Sex Chromosomes Updated content on the XIST gene product as a long noncoding RNA New insights about a novel gene involved in temperature sensitive differentiation of snapping turtles and lizards, as well as the impact of climate change on sex, sex reversal, and sex ratios Chapter 9: Extranuclear Inheritance Updated information on mtDNA disorders and nuclear DNA mismatches Chapter 11: DNA Replication and Recombination New coverage of the role of telomeres in disease, aging, and cancer New and expanded coverage of telomeres and chromosome stability , explaining how telomeres protect chromosome ends Chapter 13: The Genetic Code and Transcription New coverage on transcription termination in bacteria New section entitled Why Do Introns Exist? Updated coverage on RNA editing Chapter 14: Translation and Proteins New coverage of eukaryotic closed-loop translation, including a new figure Revised coverage of Beadle and Tatum''s classic experiments Expanded coverage on the posttranslational modifications of proteins New coverage of the insights gleaned from the crystal structure of the human 80 S ribosome Chapter 15: Gene Mutation, DNA Repair, and Transposons New and revised coverage on transposons, focusing on the mechanisms of transposition by both retrotransposons and DNA transposons, as well as a discussion of how transposition creates mutations; two new tables and five new figures are included Reorganization of mutation classification section with table summaries New and expanded coverage of human germ-line and somatic mutation rates NEW! Chapter 17: Transcriptional Regulation in Eukaryotes Revised chapter organization focuses specifically on transcriptional regulation Revised coverage of regulation of the GAL gene system in yeast with an updated figure New coverage on genetic boundary elements called insulators NEW! Chapter 18: Posttranscriptional Regulation in Eukaryotes New chapter that greatly expands upon previous coverage of posttranscriptional gene regulation in eukaryotes Revised and expanded coverage of alternative splicing and its relevance to human disease Expanded coverage on RNA stability and decay with a new figure Updated coverage of noncoding RNAs that regulate gene expression with a new figure Enriched coverage of ubiquitin-mediated protein degradation with a new figure NEW! Chapter 19: Epigenetic Regulation in Eukaryotes New chapter on Epigenetics, including coverage of epigenetics and cancer, transmission of epigenetic traits across generations, and the role of epigenetics in behavior New coverage on the recently discovered phenomenon of monoallelic expression of autosomal genes Updated coverage of epigenome projects Chapter 20: Recombinant DNA Technology Increased emphasis on the importance of whole-genome sequencing approaches New coverage of CRISPR-Cas as a gene editing approach including a new figure Updated content on next-generation and third-generation sequencing Chapter 21: Genomic Analysis Increased emphasis on the integration of genomics, bioinformatics, and proteomics approaches to analyzing genomes and understanding genome function A new section entitled Genomic Analysis Before Modern Sequencing Methods, which briefly summarizes approaches to mapping and identifying genes prior to modern sequencing Reorganized and revised content on the Human Genome Project.

Updated content on personal genome projects and new content on diploid genomes and mosaicism and the pangenome to emphasize human genetic variations New coverage of the Human Microbiome Project including a new figure displaying microbiome results of patients with different human disease conditions New coverage of in situ RNA sequencing Chapter 22: Applications of Genetic Engineering and Biotechnology Updated content on biopharmaceutical products including newly approved recombinant proteins, DNA vaccine trials to immunize against Zika virus, genetically modified organisms, and gene drive in mosquitoes to control spread of Zika New coverage of genes essential for life and how synthetic genomics is being applied to elucidate them; clarification of prognostic and diagnostic genetics tests and the relative value of each for genetic analysis New content on DNA and RNA sequencing New section entitled Screening the Genome for Genes or Mutations You Want, which discusses how scientists can look at genetic variation that confers beneficial phenotypes New section entitled Genetic Analysis by Personal Genomics Can Include Sequencing of DNA and RNA that expands coverage of personal genome projects and new approaches for single-cell genetic analysis of DNA and RNA Chapter 23: Developmental Genetic s New section entitled Epigenetic Regulation of Development New coverage of DNA methylation and progressive restriction of developmental potential Expanded coverage of binary switch genes and regulatory networks Chapter 24: Cancer Genetics Extended coverage of environmental agents that contribute to human cancers), including more information about both natural and human-made carcinogens New section entitled Tobacco Smoke and Cancer explaining how a well-studied carcinogen induces a wide range of genetic effects that may lead to mutations and cancer New section entitled Cancer Therapies and Cancer Cell Biology, describing the mechanisms of chemotherapies and radiotherapies as they relate to cancer cell proliferation, DNA repair, and apoptosis Chapter 25: Quantitative Genetics and Multifactorial Traits Updated coverage on quantitative trait loci (QTLs) Revised and expanded section eQTLs and Gene Expression Chapter 26: Population and Evolutionary Genetics New coverage on vertebrate evolution New coverage of phylogenetic trees Updated coverage on the origins of the human genome New section entitled Genotype and Allele Frequency Changes New coverage on pre-and post-zygotic isolating mechanisms NEW! Special Topics 1: CRISPR-Cas and Genome Editing New chapter on a powerful genome editing tool called CRISPR-Cas Provides up to date coverage on CRISPR-Cas applications, the patenting of this technology, and.