Beautiful and willful Audrey Sterling, the daughter of missionary parents, accepts a nursing position in Tahlequah under the guidance of Dr. Elijah Keaton, a university trained Cherokee doctor and a once consecrated shaman. Despite conflicting beliefs and cultures, Audrey and Elijah succumb to a fate they cannot deny. As their relationship grows and blossoms, they travel a trail of personal tragedy and immense joy while embracing the legacy of their time. Amid a rich blend of history and romance, A Trail of Twenty Winters is set within the unthinkable tragedy of the Cherokees' forced removal from their ancestral home in the southeastern United States to the Indian Territory in present day Oklahoma.