Willow O'Keefe is born with osteogenesis imperfecta, a brittle bone disease, which means she will suffer hundreds of broken bones as she grows, and a lifetime of pain. As the family struggles to cover medical expenses, Charlotte decides to file a wrongful birth lawsuit against her obstetrician for the monetary payouts which might ensure a lifetime of care for Willow. But it means that Charlotte has to say in a court of law that she would have terminated the pregnancy if she'd known about the disability in advance. And the obstetrician she's suing isn't just her physician - it's her best friend.Handle With Careis an absorbing narrative which also questions the basis of medical ethics and of personal morality. What rights do parents or doctors have to terminate a life? How disabled is too disabled? As a parent, how far would you go to save someone you love? Picoult is a best-seller for good reason - tight plots and a style that reads easily, but is never glib.