Preface. Contributors. PART I SYSTEMS THEORY AND COOPERATIVE BACTERIA. 1 Systems thinking in biology ( Robert M. Seymour ). 2 Metagenomics and its applications to human bacterial diseases ( Julian R. Marchesi ). PART II PERIODONTITIS: THE CLINICAL DISEASE.
3 Periodontitis: a modern clinical picture ( Nikos Donos and Francesco D'Aiuto ). 4 Plaque microbiology in (periodontal) health and disease ( Anne D. Haffajee ). 5 Population molecular genetics of periodontitis ( Marja L. Laine, Ubele van der Velden and Bruno G. Loos ). 6 Mechanisms linking periodontitis to systemic disease ( Panos N. Papapanou and Jan H.
Behle ). 7 The impact of diabetes-enhanced inflammation on periodontal disease and bone destruction ( Dana T. Graves ). PART III PERIODONTITIS: COPINGWITH THE MICROBIOTA. 8 The microbiota of humans ( Gerald W. Tannock ). 9 The normal oral microbiota ( William G. Wade ).
10 Bacterial coaggregation and periodontitis ( Paul E. Kolenbrander, Natalia I. Chalmers, Saravanan Periasamy, A.M. Ding and Shayla L. West-Barnette ). 11 Dynamics of biofilm formation and relationship to periodontitis ( Jonathan Pratten and Nicola Mordan ). 12 Quorum sensing as a means of biofilm communication ( Hanjuan Shao and Donald R.
Demuth ). 13 Genomics of Porphyromonas gingivalis ( Keisuke Nakayama ). 14 Genomics of Fusobacterium nucleatum ( Vinayak Kapatral ). 15 The Aggregatibacter (formerly Actinobacillus ) actinomycetemcomitans genome - annotation, analysis and metabolic reconstruction ( Fares Najar, Shaoping Lin, Lin Song, Hongshing Lai, James White, Steven Kenton and Bruce A. Roe ). PART IV PERIODONTITIS: INNATE AND ACQUIRED IMMUNITY. 16 A new view of innate immunity for the twenty-first century ( John Wright and Clare E. Bryant ).
17 Innate immunity and homeostasis in the periodontium ( Richard P. Darveau ). 18 Antimicrobial host defence peptides in oral health and periodontitis ( Deirdre A. Devine and Celine Cosseau ). 19 Control of inflammation in periodontal disease ( Hatice Hasturk, Alpdogan Kantarci and Thomas E. Van Dyke ). 20 Antigen-presenting cells in chronic periodontitis ( Ravi Jotwani and Christopher W. Cutler ).
21 B-cell responses in periodontitis ( Suzanne E. Barbour, John G. Tew and Harvey A. Schenkein ). 22 T-cell responses in periodontitis ( Gregory J. Seymour, Erica Gemmell and Kazuhisa Yamazaki ). PART V PERIODONTITIS: BONE DESTRUCTION. 23 Current paradigms of osteoblast-osteoclast interactions and bacterial pathogen-induced bone resorption ( Naoyuki Takahashi, Masanori Koide, Toshihide Noguchi and Tatsuo Suda ).
24 Bacterial osteolytic mediators ( Brian Henderson and Sean P. Nair ). 25 Immune cell involvement in periodontal bone loss ( Andy Y.-T. Teng ). 26 How can periodontal bone loss be stopped? ( Colin R. Dunstan ). Index.