Three grown Southern sisters have ten marriages between them - and more loom on the horizon - when Ginger, the eldest, wonders if she's the only one who hasn't inherited what their family calls "the Grandma Gene": the tendency to like the casualness of courtship better than the intimacy of marriage. Could it be that her two sisters are fated to serially marry, just like their seven-times-wed grandmother, Mrs. Lillian Irene Harper Winslow Goldstein Carey James Bobrinski Gordon George? It takes a "girls only" weekend, closing up Grandma's treasured beach house for the last time, for the sisters to really unpack their family baggage, examine their relationship DNA, and discover the true legacy their much-marrying grandmother left behind.