The 2025 5th International Conference on Computer Science and Blockchain (CCSB 2025) will be opened to original research on the intersection of computer science and blockchain technologies This event will aim to explore topics such as algorithmic innovations and the evolution of computer networks, while also delving into the role of AI through neural networks and natural language processing It will highlight blockchain advancements, including consensus protocols and decentralized systems, with a focus on performance, scalability, and security, which will be essential for applications like smart contracts and distributed ledgers Furthermore, CCSB 2025 will promote collaboration among computer scientists, blockchain developers, and industry experts, offering participants the chance to engage with thought leaders and explore new research directions amidst a rapidly changing digital landscape.