This publication provides a holistic approach to evaluate progress in the development of Member States' uranium production cycle programmes based on the guidance contained in IAEA Nuclear Energy Series No. NF-G- 1.1, Milestones in the Development of National Infrastructure for the Uranium Production Cycle. It can be used by Member States to evaluate their progress (self-evaluation), or as a basis for IAEA Integrated Uranium Production Cycle Review (IUPCR) missions. This publication is intended for government decision makers, advisors and senior managers in government, industry and regulatory bodies in Member States with responsibilities for developing or reinvigorating uranium exploration, mining, processing, decommissioning and closure.