Although more widely utilized in Europe and other parts of the world, musculoskeletal ultrasound is gaining wider acceptance in this country not only because of its ability to image anatomic structures but also because of its low cost compared with magnetic resonance. Reviewed in this issue is imaging of common tendon and muscle injuries of the upper and lower extremities, the rotator cuff, musculoskeletal infections, nerve abnormalities, soft tissue masses, and hernias among others. Also covered are the use of ultrasound in joint aspiration and percutaneous interventional procedures.