Synergy is associated with mysterious untamable force. A better understanding of the roots of synergy will allow us to increase success rates in science, in economics, in business, in everyday life, and in yet to be named novel areas. Empirical evidence in many domains show that synergy is favored by increased structured information, large fluxes of energy and information. The working of these processes can only be grasped by using a diversity of available scientific tools. Here we will submerge ourselves in an interdisciplinary journey that will lead us in the end to understand the roots of synergy and help us acquire practical knowledge in how to tame synergy and make cooperation successful.