Spider-Man and Deadpool's dream team-up is about to enter nightmare territory as they come face-to-face with Itsy-Bitsy! Created by the mysterious maniac Patient Zero, this multi-armed marauder is the result of some very unethical gene-splicing using Spidey and Deadpool's DNA. Faster, stronger and certifiably insane, she's on the loose and looking to deal some serious damage! Is this the end of comics' greatest bromance? Reprinting Spider-Man/Deadpool #9-10, #13-14 & #17-18.