The Second Cairo International Conference on High Energy Physics (CICHEP II) was held at the German University in Cairo, Egypt from 14-17 January 2006. The purpose of the conference was to bring together specialized scientists in the field of High Energy Physics from universities and research institutes from all around the world to discuss current developments and new trends, results, and perspectives in this field. As with CICHEP I, the main theme of the conference was theoretical, phenomenological, and experimental aspects of the presently most active fields of High Energy Physics.