Paperback. This book is targeted at neurologists and clinical electrophysiologists with interest in theoretical and practical aspects of ALS research and patient care.The volume gives in-depth reports of clinical aspects and treatment approaches, such as: Diagnosis and management of patients with muscular atrophies including those suspected of having ALS; Clinical and electrophysiologic aspects useful in differentiating treatable muscular atrophies from ALS; Pros and cons for the concept of a purely immune-mediated motor neuron disease; Frontiers of research as relating to the pathophysiology of ALS as well as reliable measures for clinical trials.