Preface v Contributors vii 1 Aalen's Additive Risk Model 1 2 Aggregation 9 3 AIDS Stochastic Models 15 4 All-or-None Compliance 37 5 Ascertainment Sampling 43 6 Assessment Bias 47 7 Bioavailability and Bioequivalence 53 8 Cancer Stochastic Models 61 9 Centralized Genomic Control: A Simple Approach Correcting for Population Structures in Case-Control Association Studies 81 10 Change Point Methods in Genetics 95 11 Classical Biostatistics 117 12 Clinical Trials-II 131 13 Cluster Randomization 143 14 Cohort Analysis 157 15 Comparisons with a Control 167 16 Competing Risks 179 17 Countermatched Sampling 189 18 Counting Processes 193 19 Cox's Proportional Hazards Model 203 20 Crossover Trials 215 21 Design and Analysis for Repeated Measurements 225 22 DNA Fingerprinting 259 23 Epidemics 269 24 Epidemiological Statistics I 279 25 Epidemiological Statistics II 299 26 Event History Analysis 319 27 FDA Statistical Programs: An Overview 329 28 FDA Statistical Programs: Human Drugs 335 29 Follow-Up 343 30 Frailty Models 349 31 Framingham: An Evolving Longitudinal Study 353 32 Genetic Linkage 359 33 Group-Sequential Methods in Biomedical Research 365 34 Group-Sequential Tests 377 35 Grouped Data in Survival Analysis 391 36 Image Processing 397 37 Image Restoration and Reconstruction 415 38 Imputation and Multiple Imputation 425 39 Incomplete Data 441 40 Interval Censoring 451 41 Interrater Agreement 461 42 Kaplan-Meier Estimator I 481 43 Kaplan-Meier Estimator II 489 44 Landmark Data 501 45 Longitudinal Data Analysis 515 46 Meta-Analysis 531 47 Missing Data: Sensitivity Analysis 535 48 Multiple Testing in Clinical Trials 547 49 Mutation Processes 555 50 Nested Case-Control Sampling 559 51 Observational Studies 567 52 One- and Two-Armed Bandit Problems 573 53 Opthalmology 579 54 Panel Count Data 585 55 Planning and Analysis of Group-Randomized Trials 605 56 Predicting Preclinical Disease Using the Mixed-Effects Regression Model 613 57 Predicting Random Effects in Group-Randomized Trials 635 58 Probabilistic and Statistical Models for Conception 647 59 Probit Analysis 669 60 Prospective Studies 677 61 Quality Assessment for Clinical Trials 683 62 Repeated Measurements 695 63 Reproduction Rates 709 64 Retrospective Studies 713 65 Sample Size Determination for Clinical Trials 719 66 Scan Statistics 733 67 Semiparametric Analysis of Competing-Risk Data 749 68 Size and Shape Analysis 769 69 Stability Study Designs 781 70 Statistical Analysis of DNA Microarray Data 795 71 Statistical Genetics 801 72 Statistical Methods in Bioassay 807 73 Statistical Modeling of Human Fecundity 815 74 Statistical Quality of Life 839 75 Statistics at CDC 865 76 Statistics in Dentistry 871 77 Statistics in Evolutionary Genetics 873 78 Statistics in Forensic Science 879 79 Statistics in Human Genetics I 887 80 Statistics in Human Genetics II 893 81 Statistics in Medical Diagnosis 909 82 Statistics in Medicine 915 83 Statistics in the Pharmaceutical Industry 927 84 Statistics in Spatial Epidemiology 933 85 Stochastic Compartment Models 939 86 Surrogate Markers 945 87 Survival Analysis 953 Index 967.