PART I: Introduction: An Overview of Computing with Macromolecular Sequences PART II: Sources of Information 1. Databanks of Protein Sequences: A. The NBRF Databank B. Peptide and Protein Databanks in Japan C. Additional Protein Sequence Databanks 2. Databanks of Nucleic Acid Sequences: A. GenBank B. The EMBL Data Library 3.

Databanks of Three-Dimensional Structures A. The Protein Databank PART III: Program Systems 4. Computer Access to Sequence Databanks 5. The Protein Identification Resource (PIR) Software 6. Program Systems for minicomputers PART IV: The Technical Background 7. Gels to Sequences 8. Computers in Modern Science 9. An Introduction to Computer Networking PART V: Scientific Applications 10.

Sequence Comparison and Alignment: The Measurement and Interpretation of Sequence Similarity 11. Analysis of DNA Sequence Data 12. Prediction of Secondary Structure of Proteins 13. Hydrophobicity Profiles 14. Molecular Evolution 15. Conclusion: What Shall One Do with a Newly-Determined Sequence? PART VI: Prospects 16. The Future of Computational Molecular Biology.