Chapter 1: The photosynthetic reaction centre: protein structure in a microcosm The reaction centre from Rhodopseudomonas viridis Conclusions Recommended reading and references Exercises and problems Chapter 2: In vivo, in vitro, in silico Why study proteins? Protein structure and conformation The known protein sequences The protein data bank The World-Wide Web Summary Glossary Useful Web sites Recommended reading and references Exercises, problems and weblems Chapter 3: Pattern and form in protein structure Helices and sheets The heirarchical nature of protein architecture An album of small structures Classification of protein structures Loops Protein-ligand interactions Useful Web sites Recommended reading and references Exercises, problems, and weblems Chapter 4: The varieties of protein structure Catalogues of protein structure The known structures alpha-helical proteins beta-sheet proteins alpha + beta proteins alpha/beta proteins Closed beta-alpha-beta barrel structures Irregular structures Conclusions Useful web sites Recommended reading and references Exercises, problems, and weblems Chapter 5: Molecular evolution Evolution of protein structures Structural relationships among related molecules Useful web sites Recommended reading and references Exercises, problems, and weblems Chapter 6: Evolution in selected protein families Evolution of the globins Evolution of serine proteinases of the chymotrypsin family NAD-binding domains of dehydrogenases Useful web sites Recommended reading and references Exercises, problems, and weblems Chapter 7: Some proteins of the immmune system Antibody structure Proteins of the Major Histocompatibility Complex T cell receptors Useful web sites Recommended reading and references Exercises, problems, and weblems Chapter 8: Conformational changes in proteins Structural changes arising from change in state of ligation Hinge motions in proteins The helix interface shear mechanism of conformational change The allosteric change in haemoglobin Serpins: SERine Proteinase Inhibitors Higher-level structural changes Index.