This open access book explores the network design and planning of platform-based supply chains in four chapters based on mathematical modeling, algorithm analysis, and numerical experiments. The main research methodologies in this book include mathematical modeling, linear programming, integer and combinatorial programming, and stochastic and robust optimization. What makes the book unique is the new insights into network design and planning for platform-based supply chains, which differ from those for traditional supply chains. This makes the subject in this book of significance, although there are abundant existing works on relevant topics for traditional supply chains. Another important feature of this book is the systematic perspective to unify network design in deterministic and uncertain settings for platform-based supply chains. By summarizing the new research results obtained from the implementation of a national project on platform-based supply chain, this provides a generalized scope on network design and planning for large-scale supply chains.