In an instant, a mysterious phenomenon plunges people everywhere into crazed hysteria. Amidst the anarchy, a lone survivor fights for his life while searching for the woman he loves. But for him, the battle may already be lost.Aboard Flight 75 to Los Angeles, Matthew Hayes's plans for a lucrative screenwriting career are disrupted when a widespread brawl breaks out mid-flight, the passengers and crew lashing out with a ferocious rage. Hayes and other unaffected passengers manage to land the plane, only to discover the disease has spread over the ground and they are now being hunted by a mob of unhinged people hell-bent on murder and violence. Frantic to find his fiancée-to-be, Hayes treks home across hostile countryside. But there is a catch: he never should have survived the phenomenon. In fact, the disease is alive inside of him, slowly taking control.

It is a race against the clock as Hayes struggles to get home, fighting the devil within as the insanity begins to pull him under.