Chapter 01 The advantages and versatility of carrier-free nanodrugs and nanoparticles systems for cancer therapy Chapter 02 Strategies, design, and chemistry in siRNA delivery vehicles systems for cancer therapy Chapter 03 DNA/RNA nanoparticles structures for siRNA deliver applications Chapter 04 Co-delivery in nanoparticle-based siRNA for cancer therapy Chapter 05 Small interfering RNAs (siRNAs), MicroRNAs and NPs in gynecological cancers Chapter 06 Nanoparticle-based RNA (siRNA) combination therapy toward overcoming drug resistance in cancer Chapter 07 Imaging modalities delivery of RNAi therapeutics in cancer therapy and clinical applications Chapter 08 Recent development of Silica nanoparticles as delivery biomedical applications for cancer imaging and therapy Chapter 09 Application of carbon nanotubes (CNTs) in cancer vaccines as drug delivery tools Chapter 10 Development of oligonucleotides delivery, (siRNAs), and (miRNA) systems for anticancer therapeutic strategy immunotherapy Chapter 11 Pharmacogenomics-synergistic strategies using a chimerical peptide for enhanced chemotherapy based on ROS and DNA nanosystem Chapter 12 Pharmacokinetics, biodistribution and therapeutic applications of recently-developed siRNA and DNA repair genes recurrence Chapter 13 Nanotechnologies assemblies of siRNA and chemotherapeutic drugs co-delivered for cancer therapeutic applications Chapter 14 Targeted systemic combinatorial delivery of siRNA polyplexes-Functional quantum dot-siRNA nanoplexes Chapter 15 Recent advances of nanotechnologies for cancer immunotherapy treatment List of Abbreviations.