This issue of the Surgical Oncology Clinics of North America, Guest Edited by Dr. Greg Masters, will highlight the multi-disciplinary approach to a variety of common malignancies, focusing on how surgical oncologists work together with medical oncologists and radiation oncologists to provide the most up-to-date management for many different malignancies. It will focus on the latest data from updates in basic science and clinical trials, including the importance of new technology and surgical techniques, new radiation techniques and the latest in chemotherapy, biologic, and targeted drug development in the multidisciplinary care of cancer patients.