Carefully chosen from among almost 1000 autopsies performed at large teaching hospitals in a 35-year career in anatomic pathology, are 19 autopsies that represent classically important or interesting diseases. The cases have high quality color gross and microscopic images and discussions of the pathologic findings, key pathophysiologic features, associated stories from medical history, and relevant medical laboratory science. They have been organized using the mnemonic VINDICATE to help the reader relate the findings to the major classes of disease. All the discussions are referenced and have study questions for further investigation. This text serves as a companion for the study of pathology and pathophysiology at the undergraduate and graduate levels.