Preface xvii Acknowledgments xix Walkthrough of Pedagogical Features xxi Companion Website xxii Section I: The Neurobiology of Thinking 1 1 Introduction and History 4 Key Themes 4 A Brief (and Selective) History 6 Construct validity in models of cognition 6 Localization of function vs. mass action 7 The first scientifically rigorous demonstrations of localization of function 9 What is a Brain and What Does It Do? 12 Looking Ahead to the Development of Cognitive Neuroscience 13 End-of-Chapter Questions 14 References 14 Other Sources Used 14 Further Reading 15 2 The Brain 16 Key Themes 16 Pep Talk 18 Gross Anatomy 18 The cerebral cortex 21 The Neuron 23 Electrical and chemical properties of the neuron 23 Oscillatory Fluctuations in the Membrane Potential 28 Neurons are never truly "at rest" 28 Oscillatory synchrony 29 Complicated, and Complex 31 End-of-Chapter Questions 32 References 32 Other Sources Used 33 Further Reading 33 3 Methods for Cognitive Neuroscience 34 Key Themes 34 Behavior, Structure, Function, and Models 36 Behavior 36 Neuropsychology, neurophysiology, and the limits of inference 36 Different kinds of neuropsychology address different kinds of questions 37 How does behavior relate to mental functions? 38 Methods for lesioning targeted areas of the brain 39 Nonlocalized trauma 39 Transcranial Neurostimulation 40 The importance of specificity (again) 41 Transcranial magnetic stimulation 43 Anatomy and Cellular Physiology 47 Techniques that exploit the cell biology of the neuron 48 Electrophysiology 51 Invasive recording with microelectrodes: action potentials and local field potentials 51 Electrocorticography 53 Electroencephalography 53 Magnetoencephalography 55 Invasive Neurostimulation 55 Electrical microstimulation 55 Optogenetics 55 Analysis of Time-Varying Signals 56 Event-related analyses 56 Magnetic Resonance Imaging 61 Physics and engineering bases 61 MRI methods for in vivo anatomical imaging 64 Functional magnetic resonance imaging 65 Functional connectivity 70 Resting state functional correlations 70 Magnetic Resonance Spectroscopy 73 Tomography 73 X-ray computed tomography 73 Positron emission tomography 73 Near-Infrared Spectroscopy 76 Some Considerations For Experimental Design 76 Computational Models and Analytic Approaches 78 Neural network modeling 78 Network science and graph theory 82 End-of-Chapter Questions 84 References 85 Other Sources Used 86 Further Reading 86 Section II: Sensation, Perception, Attention, and Action 87 4 Sensation and Perception of Visual Signals 90 Key Themes 90 The Dominant Sense in Primates 92 Organization of the Visual System 92 The visual field 92 The retina and the LGN of the thalamus 92 The retinotopic organization of primary visual cortex 93 The receptive field 95 Information Processing in Primary Visual Cortex - Bottom-Up Feature Detection 96 The V1 neuron as feature detector 96 Columns, hypercolumns, and pinwheels 99 Information Processing in Primary Visual Cortex - Interactivity 100 Feedforward and feedback projections of V1 100 The relation between visual processing and the brain''s physiological state 104 Where Does Sensation End? Where Does Perception Begin? 106 End-of-Chapter Questions 106 References 107 Other Sources Used 107 Further Reading 108 5 Audition and Somatosensation 109 Key Themes 109 Apologia 111 Audition 111 Auditory sensation 111 Auditory perception 115 Adieu to audition 119 Somatosensation 119 Transduction of mechanical and thermal energy, and of pain 119 Somatotopy 122 Somatosensory plasticity 126 Phantom limbs and phantom pain 129 Proprioception 131 Adieu to sensation 131 End-of-Chapter Questions 131 References 132 Other Sources Used 132 Further Reading 132 6 The Visual System 134 Key Themes 134 Familiar Principles and Processes, Applied to Higher-Level Representations 136 Two Parallel Pathways 136 A diversity of projections from V1 136 A functional dissociation of visual perception of what an object is vs. where it is located 137 Interconnectedness within and between the two pathways 142 The Organization and Functions of the Ventral Visual Processing Stream 144 Hand cells, face cells, and grandmother cells 144 Broader implications of visual properties of temporal cortex neurons 149 A hierarchy of stimulus representation 150 Object-based (viewpoint-independent) vs. image-based (viewpoint-dependent) representation in IT 153 A critical role for feedback in the ventral visual processing stream 153 Taking Stock 158 End-of-Chapter Questions 158 References 159 Other Sources Used 159 Further Reading 160 7 Spatial Cognition and Attention 161 Key Themes 161 Unilateral Neglect: A Fertile Source of Models of Spatial Cognition and Attention 163 Unilateral neglect: a clinicoanatomical primer 163 Hypotheses arising from clinical observations of neglect 164 The Functional Anatomy of the Dorsal Stream 166 Coordinate transformations to guide action with perception 169 From Parietal Space to Medial-Temporal Place 172 Place cells in the hippocampus 173 How does place come to be represented in the hippocampus? 175 The Neurophysiology of Sensory Attention 175 A day at the circus 176 Attending to locations vs. attending to objects 176 Mechanisms of spatial attention 180 Effects of attention on neuronal activity 181 Turning Our Attention to the Future 185 End-of-Chapter Questions 185 References 186 Other Sources Used 186 Further Reading 187 8 Skeletomotor Control 188 Key Themes 188 The Organization of the Motor System 190 The anatomy of the motor system 190 The corticospinal tract 190 The cortico-cerebellar circuit 190 The cortico-basal ganglia-thalamic circuits 192 Functional Principles of Motor Control 193 The biomechanics of motor control 193 Motor cortex 196 The neurophysiology of movement 196 Motor Control Outside of Motor Cortex 202 Parietal cortex: guiding how we move 202 A neurological dissociation between perceiving objects and acting on them 203 Cerebellum: motor learning, balance, . and mental representation? 204 Synaptic plasticity 205 Basal ganglia 206 Cognitive Functions of the Motor System 211 Mirror neurons 212 Holding a mirror up to nature? 213 It''s All About Action 214 End-of-Chapter Questions 214 References 215 Other Sources Used 215 Further Reading 216 9 Oculomotor Control and the Control of Attention 218 Key Themes 218 Attention and Action 220 Whys and Hows of Eye Movements 220 Three categories of eye movements 220 The Organization of the Oculomotor System 221 An overview of the circuitry 221 The superior colliculus 222 The posterior system 222 The frontal eye field 223 The supplementary eye field 223 The Control of Eye Movements, and of Attention, In Humans 224 Human oculomotor control 224 Human attentional control 226 The Control of Attention via the Oculomotor System 227 Covert attention 227 Where''s the attentional controller? 230 Are Oculomotor Control and Attentional Control Really the "Same Thing"? 233 The "method of visual inspection" 234 "Prioritized maps of space in human frontoparietal cortex" 235 Of Labels and Mechanisms 238 End-of-Chapter Questions 238 References 238 Other Sources Used 239 Further Reading 240 Section III: Mental Representation 241 10 Visual Object Recognition and Knowledge 243 Key Themes 243 Visual Agnosia 245 Apperceptive agnosia 245 Associative agnosia 245 Computational Models of Visual Object Recognition 247 Two neuropsychological traditions 247 The cognitive neuroscience revolution in visual cognition 249 Category Specificity in the Ventral Stream? 249 Are faces special? 249 Perceptual expertise 251 Evidence for a high degree of specificity for many categories in ventral occipitotemporal cortex 252 Evidence for highly distributed category representation in ventral occipitotemporal cortex 253 Demonstrating necessity 256 The code for facial identity in the primate brain (!?!) 258 Visual Perception as Predictive Coding 261 Playing 20 Questions With the Brain 262 End-of-Chapter Questions 264 References 264 Other Sources Used 265 Further Reading 265 11 Neural Bases of Memory 267 Key Themes 267 Plasticity, Learning, and Memory 269 The Case of H.M. 269 Bilateral medial temporal lobectomy 269 Hippocampus vs.

MTL? 272 Association Through Synaptic Modification 273 Long-term potentiation 273.