Guy Quigley was born in Ireland to a second-generation thespian family. He was educated in Ireland, where he left the theatre and entered the business world. He is married with three children and has six grandchildren. From 1970 through the early 80s, he built a 40,000-acre cattle ranch in Zambia, Africa housing 5,000 heads of cattle and imported 100 pedigree Semmintaler cattle from Bavaria, Germany, via three Boeing 707 Skybarn aircraft, establishing the first pedigree Semmintaler stud in the south-central African country.In his spare time, he wrote two fictional novels - one, a children's story, The Little People, and the other, The Smoke That Thunders, published in England in 1983 and now republished as a Second Edition under the original title, The Smoke That Thunders. In the U.S., he formed The Quigley Corporation in 1989, filed an S-18 registration, and the company became a public entity on February 7, 1991, trading on the NASDAQ under the symbol (QGLY).

He successfully developed and marketed a cold remedy zinc product under the franchise name COLD-EEZE®, establishing the United States zinc-lozenge marketplace. The product remains on the shelves of most outlets in the United States. He retired in 2009. His writing has been of tremendous therapeutic value and comes full circle to his birth roots. He has written two more books, The Rebel Son and Hellevator (The Master's Son), along with several award-winning movie scripts. He is one of the ex-producers of Magic Boys filmed in London and Budapest. He is also an ex-producer of the spoof Breaking Wind and the ex-producer of Wicked Blood. He joined forces with Futurist Ape Productions, utilizing his ThunderSmoke Media Company to collectively produce the 2015 award-winning movie Apparition.

Along with a partner, he is currently pre-producing a new movie entitled 'Impuratus.'.