#A Techniques Applicable to Metabolite Investigation.- #A-1 Strategies centered on HPLC.- #A-2 Preparative liquid-chromatographic methods in drug metabolism studies.- #A-3 Problems arising from assaying low concentrations HPLC.- #A-4 Extraction of drugs and metabolites from plasma and urine.- #A-5 The use of long capillary GC columns for urinary phenolic acids from catecholamines and analogues.- #A-6 Quantitative HPTLC in assaying body fluids for drugs and metabolites.- #NC(A) NOTES and COMMENTS related to the foregoing topics.
- #NC(A)-1 TLC densitometry for drug and metabolite determination.- #NC(A)-2 Taking aliquots from small volumes of upper phases.- #NC(A)-3 Rapid removal of fine particles from alumina for column chromatography.- #NC(A)-4 Assessment of radioactivity measurements on HPLC effluents.- #NC(A)-5 Quantitation of14C radioactivity in HPLC eluates.- #B Investigation of Metabolites, Especially Phase I.- #B-1 Examples of approaches to isolating and identifying Phase I metabolites.- #B-2 The identification of amitriptyline and benzodiazepine metabolites.
- #B-3 A novel use of RIA and HPLC in the identification of plasma metabolites of HR 158.- #B-4 Investigation of pesticide metabolites in the human.- #NC(B) NOTES and COMMENTS relating to the foregoing topics.- #NC(B)-1 Metabolic fate of the immunoadjuvant peptidoglycan monomer.- #NC(B)-2 HPLC as a means of following anin vitrosynthesis of 7-hydroxymethotrexate.- #C Investigation of Conjugates.- #C-1 Isolation of conjugates and identification of the attached groups.- #C-2 Isolation and characterization of amino acid and sugar conjugates of xenobiotic carboxylic acids.
- #C-3 Chromatography, hydrolysis and rearrangement of the glucuronide conjugates of isoxepac, as affecting its assay in urine.- #NC(C) NOTE and COMMENTS relating to the foregoing topics.- #NC(C)-1 Isolation and identification of a drug conjugate.- #D Determination of Particular Mugs and Metabolites.- #D-1 HPLC analysis of the major urinary metabolite of flurazepam.- #D-2 Quantification of metabolites of aminopyrine and antipyrine in plasma and urine.- #D-3 Immunoassay of bromcriptine and specificity of antibody: criteria for choice of antiserum and marker compound.- #D-4 Determination of 3-phenoxy-N-methylmorphinan and metabolites in plasma.
- #D-5 Assays where high sensitivity was achieved, especially by HPTLC with automatic spotting and colour reactions.- #NC(D) NOTES and COMMENTS on drug and metabolite determinations.- #NC(D)-1 Selective column-extraction of psycho-active drugs and metabolites.- #NC(D)-2 Determination of atracurium and its metabolites.- #NC(D)-3 Discrimination between carbon monoxide as a metabolite of carbon tetrachloride and as a degradation product of the biological material.- #NC(D)-4 HPLC determination of cefotaxime and its metabolites.- #E Metabolite Methodology: The State-of-Play.- Cumulative Index of Compound Types, Covering Vols.
5, 7 & 10 also.- General Index.- Corrections to Vols. 10 & 11.