For the last 4 decades, Israel has been challenged by the rise of ballistic arsenals in the Middle East. If, at first, the country kept relying on its traditional offensive doctrines, it eventually developed missile defense programs in the early-1980s through U.S.-Israel cooperation and then in the 2000s with the building of its iconic Iron Dome. This Israeli experience in missile defense reveals crucial lessons on the military adaptation to both new threats and new remedies that have direct implications for the United States and its allies.