Preface 1.Breeding a Perfect Society Beginnings: Davenport and eugenics in the United States * IQ and involuntary sterilization * Genetics against eugenics * Exporting sterilization * The Watson scandal * Davenport's dreams today 2.Molecular Diseases, Elusive Treatments The molecularization of biology * Molecular diseases * But no molecular medicine *Dreams of editing genes * Followed by stunning failure * Recombinant DNA made no difference * Gene editing BC 3.What Good Was the Human Genome Project? The sequence revealed * Common diseases and common variants * Medical irrelevance of the sequence * Critiques of the HGP, past and present * Evolution and architecture of the genome * Evolutionary contingency 4.The CRISPR Revolution The CRISPR structure emerges * Its function is decoded * The mechanism of immunity * Onward to gene editing * The delivery problem * Ubiquitous CRISPR 5.Inevitable Eugenics? Eugenics in the news * What is eugenics? * Defining eugenics * A working definition * Inescapable eugenics? * Matters of ethics 6.Eliminating Genetic Diseases The long reach of Huntington's disease * The He Jiankui affair * The ethics of human germ-line intervention * The limits of current science * Gene specificity and Lenin's brain * A policy proposal * Proceed with caution * Liberal and moderate eugenics 7.Designer Baby Delusions Why not genetic enhancement? * The normal and the enhanced * Liberal eugen- ics and genetic enhancement * Rationality of genetic enhancement * Planned human obsolescence * Where is the science? The case of intelligence * Genomics and IQ * What about physical traits * Genetic reductionism * Contextual developmental construction * What is perfection? 8.

A CRISPR Future Editing the human germ-line * Gene drives * The ethics of promoting extinction *Biosecurity * CRISPR without the hype.