Mitochondrial Biogenesis and Respiratory Chain Structure; Clinical Features of The Mitochondrial Encephalomyopathies; Molecular Genetic Basis of The Mitochondrial Encephalomyopathies; Leber's Hereditary Optic Neuropathy; Mitochondrial Abnormalities In Neurodegenerative Disorders; Mouse Models of Mitochondrial Disease; Current and Future Prospects for The Treatment of Mitochondrial Disorders; Defects of Pyruvate Dehydrogenase and Intermediary Metabolism; Defects of -Oxidation; Future Prospects.