The My Life With . series presents infrequently discussed family challenges in an accessible and authentic manner that even the youngest readers can relate to. Each title offers a first-person narrative from the perspective of a real-life young person navigating a particular life experience, without shying away from tough topics. In My Life with a Blended Family, Karson shares how her family structure involves splitting time between her parents' two homes and navigating life with her stepdad and new siblings. Joseph's parents also split up in My Life with Divorced Parents, leading to a period of housing instability before finding a new home and routine for their restructured family. In My Life with a Foster Family, Shaylee discusses her experience in foster care and her eventual adoption by her foster family. While she initially struggles, she finds support through talking with a therapist. My Life with Losing a Parent addresses how the sudden death of Scarlett's father resulted in months of stress until the girl began speaking with her mom and a therapist to find a new normal.

Back matter in each book includes a brief biography of the child interviewed for the book plus tips, a glossary, further reading, and helpful websites. The children featured are racially and socioeconomically diverse, and the books include a dyslexic-friendly font to promote accessibility.