Prophetic chain-smoking bisexual, Mantis, finds herself in the midst of a demon apocalypse and seeks help from her estranged friend, Black-Eyed Betty, a born-again former prostitute. It isn't until Betty's seven-year-old son, Gabriel, is abducted, that the unlikely duo joins forces on a nightmarish -- and at times, comedic -- journey to rescue the boy. Soon, a bubbly exotic dancer and her smitten co-worker are recruited to as fellow demon slayers on Mantis' hilarious, hellish misadventure. With Mantis at the helm, the flock of misfit degenerates set out on a bizarre thrill-ride through the quirky American South, battling sinister creatures, chasing painful memories, staring down the devil, and negotiating with a slew of twisted characters for scattered pieces of a mysterious holy relic.