Section One - Tumour 1 - Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma 2 - MGMT gene silencing and benefit from temozolomide in glioblastoma 3 - Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial 4 - A randomized trial of surgery in the treatment of single metastases to the brain 5 - Prognostic factors for survival in adult patients with cerebral low-grade glioma 6 - Long-term outcomes after supratotal resection of diffuse low-grade gliomas: a consecutive series with 11-year follow-up 7 - The recurrence of intracranial meningiomas after surgical treatment 8 - Phase I/II study of resection and intraoperative cesium-131 radioisotope brachytherapy in patients with newly diagnosed brain metastases 9 - Natural history of asymptomatic colloid cysts of the third ventricle Section Two - Vascular 10 - Surgical Risk as Related to Time of Intervention in the Repair of Intracranial Aneurysms 11 - International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial 12 - International Study of Unruptured Intracranial Aneurysms Investigators. (ISUIA2) Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. 13 - Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial 14 - A proposed grading system for arteriovenous malformations 15 - Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials 16 - Benefit of Carotid Endarterectomy in Patients with Symptomatic Moderate or Severe Stenosis. North American Symptomatic Carotid Endarterectomy Trial (NASCET) 17 - Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage (ENRICH) Section Three - Paediatrics 18 - Randomized trial of cerebrospinal fluid shunt valve design in pediatric hydrocephalus. 19 - Endoscopic third ventriculostomy in the treatment of childhood hydrocephalus 20 - Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multicentre, single-blinded, randomised trial and economic evaluation 21 - A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele (MOMS trial) 22 - Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants less than 1,500 gm. 23 - Intrinsic brain-stem tumors of childhood: surgical indications 24 - Molecular subgroups of medulloblastoma: the current consensus 25 - Pial Synangiosis for Moyamoya Syndrome in Children 26 - Hypothermia Therapy after Traumatic Brain Injury in Children Section Four - Functional/Epilepsy 27 - The first clinical trial to establish deep brain stimulation of the subthalamic nucleus as an evidence-based treatment for Parkinson''s disease 28 - The Long-term Outcome of Microvascular Decompression for Trigeminal Neuralgia 29 - A Randomized, Controlled Trial of Surgery for Temporal-Lobe Epilepsy 30 - Early Identification of Refractory Epilepsy 31 - Vagus nerve stimulation for treatment of partial seizures: 1. A controlled study of effect on seizures 32 - Intracarotid injection of sodium amytal for the lateralization of cerebral speech dominance Section Five - Head Trauma 33 - Assessment of coma and impaired consciousness. A practical scale 34 - Traumatic Acute Subdural Hematoma: Major Mortality Reduction in Comatose Patients Treated within Four Hours 35 - Use of drains versus no drains after burr-hole evacuation of chronic subdural haematoma: a randomised controlled trial 36 - Significance of intracranial hypertension in severe head injury 37 - A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures 38 - Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months.

39 - Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension (RESCUEicp trial). 40 - Surgical Management of Acute Epidural Hematomas Section Six - Spine Trauma 41 - Validity of a Set of Clinical Criteria to Rule Out Injury to the Cervical Spine in Patients with Blunt Trauma 42 - The subaxial cervical spine injury classification system: a novel approach to recognize the importance of morphology, neurology, and integrity of the disco-ligamentous complex 43 - A new classification of thoracolumbar injuries: the importance of injury morphology, the integrity of the posterior ligamentous complex, and neurologic status 44 - A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Use of Methylprednisolone Sodium Succinate Section Seven - Spine 45 - Effect of High-dose Dexamethasone in Carcinomatous Metastatic Spinal Cord Compression Treated with Radiotherapy: a Randomised Trial 46 - Direct Decompressive Surgical Resection in the Treatment of Spinal Cord Compression Caused by Metastatic Cancer: A Randomised Trial 47 - Surgical vs nonoperative treatment for lumbar disc herniation: the Spine Patient Outcomes Research Trial (SPORT): a randomized trial 48 - Cauda Equina Syndrome Secondary to Lumbar Disc Herniation: A Meta-Analysis of Surgical Outcomes 49 - Surgical vs nonsurgical therapy for lumbar spinal stenosis 50 - The anterior approach for removal of ruptured cervical disks.