Chapter 1. Tolerance and the regulation of Immunity Tolerance T Cell Tolerance Central T Cell Tolerance Negative Selection Receptor Editing Peripheral T Cell Tolerance Clonal Anergy B Cell Tolerance Peripheral B Cell Tolerance Duration of Tolerance Chapter 2. Mechanisms of Autoimmunity Induction of Autoimmunity Normal Immune Responses Antigens Hidden in Cells or Tissues (Cryptic Antigens) Antigens Generated by Molecular Changes Receptor Editing Abnormal Immune Responses Failure of Regulatory Control Infection-Induced Autoimmunity Molecular Mimicry Epitope Spreading Bystander Activation Microchimerism Predisposing Factors Genetic Predisposition Breed Predispositions Intestinal Microbiota Chapter 3. Pathogenesis of Autoimmune Diseases Mechanisms of Tissue Damage in Autoimmunity Type I Hypersensitivity Type II Hypersensitivity Type III Hypersensitivity Type IV Hypersensitivity Chapter 4. Autoimmune Endocrine Diseases Lymphocytic Thyroiditis Hyperthyroidism Lymphocytic Parathyroiditis Autoimmune Diabetes Mellitus Atrophic Lymphocytic Pancreatitis Autoimmune Adrenalitis Chapter 5. Autoimmune Neurologic Diseases Equine Polyneuritis Canine Polyneuritis Steroid-Responsive Meningitis-Arteritis Necrotizing Meningoencephalitis Degenerative Myelopathy Cerebellar Degeneration Chapter 6. Autoimmune Eye Diseases Equine Recurrent Uveitis Uveodermatological Syndrome Immune-mediated Keratoconjunctivitis Keratoconjunctivitis Sicca Chronic Superficial Keratitis Chapter 7. Autoimmune Reproductive Diseases Infertility Contraceptive vaccines Chapter 8.
Autoimmune Skin Diseases Hair Follicle Diseases Alopecia Areata Blistering Diseases Skin Basement Membrane Diseases Bullous Pemphigoid Linear Immunoglobulin A Dermatosis Epidermolysis Bullosa Acquisita Relapsing Polychondritis Chapter 9. Autoimmune Blood diseases Immune-Mediated Hemolytic Anemia Immune Suppression of Hematopoiesis Autoimmune Thrombocytopenia Chapter 10. Autoimmune Muscle diseases Myasthenia Gravis Polymyositis Autoimmune Masticatory Myositis Canine Cardiomyopathy Dermatomyositis Chapter 11. Autoimmune Liver and Kidney Diseases Chronic Active Hepatitis Autoimmune Nephritis Chapter 12. Systemic Lupus Erythematosis Pathogenesis Genetic factors T cell abnormalities B cell abnormalities Impaired Apoptosis Multiple Autoantibodies Equine Lupus Canine Lupus Feline Lupus Diagnosis Treatment Discoid Lupus Erythematosus Sjögren''s Syndrome Chapter 13. Erosive Autoimmune Polyarthritis Rheumatoid Arthritis Pathogenesis Diagnosis Treatment Chapter 14. Non-Erosive polyarthritis Equine Polyarthritis/Polysynovitis Canine Polyarthritis Lupus Polyarthritis Polyarthritis with Polymyositis Idiopathic Polyarthritis Feline Polyarthritis Cruciate Ligament Rupture Chapter 15. Immune-mediated vasculitides Immune Vasculitis Chapter 16.
Diagnosis of Autoimmune Diseases Immunofluorescence assays Serologic assays Hemagglutinins Antiglobulin tests Rheumatoid factors Inflammation assays LE cell tests Acute Phase proteins Chapter 17. Treatment of Autoimmune Diseases Nonspecific Immunosuppression Glucocorticosteroids Cytotoxic Drugs Alkylating Agents Folic Acid Antagonists DNA Synthesis Inhibitors Selective Immunosuppression Calcineurin Inhibitors Target of Rapamycin Inhibitors Depletion of Lymphocytes Intravenous Immunoglobulin Therapy Cytokines and Monoclonal Antibodies Chapter 18. Autoimmunity in Laboratory Animals Autoimmune mouse strains NZB and NZW mice Other mouse strains Other autoimmune models.