Lysosomal Pathophysiology of Parkinson's Disease
Lysosomal Pathophysiology of Parkinson's Disease
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Author(s): Volta, Mattia
ISBN No.: 9780443240508
Pages: 300
Year: 202611
Format: Trade Paper
Price: $ 244.23
Dispatch delay: Dispatched between 7 to 15 days
Status: Available (Forthcoming)

Dr. Volta is a Senior Researcher and Team Leader at Eurac Research, in Italy. He has worked in Parkinson's disease for his whole career, applying several complementary approaches in vitro and in vivo to better understand the causes of the disease and how to tackle them therapeutically. His current team has developed a strong focus on the investigation of the autophagy-lysosome pathway, assessing how it is affected by genes linked to Parkinson's and identifying novel molecular mechanisms that could underlie disease etiology. This mechanistic effort is aimed at nominating and validating novel, effective targets for neuroprotection. Dr. Beccano-Kelly is a UKRI Future Leader Fellow and expert on synaptic dysfunction in Parkinson's disease. With a degree in Biochemistry and over 17 years of neurodegenerative research experience, he has numerous publications in the field of electrophysiology, molecular mechanism in neurodegenerative conditions.


His particular focus has been on Parkinson's, utilizing various models of the disease including induced pluripotent stem cells and murine models. Via assessment of late-onset disease causing mutations in critical genes (LRRK2, GBA, VPS35, DNAJC13) his target has been to recapitulate the insidious and progressive nature of Parkinson's disease in an effort to understand the pathophysiological timeline and identify ways in which to intervene with the disease process.


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