Part 1: A molecular reappraisal of Parkinson's disease 1. Clinical and neuropathological presentation of Parkinson's disease 2. The genetic revolution: towards an etiology-based view 3. Neuronal processes involved in etiology 4. Non-neuronal mechanisms of disease 5. The autophagy-lysosome pathway as convergence point of pathogenesis Part 2: Autophagy-Lysosome function in Parkinson's pathophysiology 6. Molecular biology of the autophagy pathway 7. The functional roles of lysosomes 8.

Physiology of lysosomes in the critical electrophysiological function of neurons 9. Lysosomes in Parkinson's disease neuropathology 10. Lysosomal dysfunction in Parkinson's disease etiology Part 3: Therapeutic options targeting lysosome biology 11. Current therapies for PD 12. Targeting options in lysosome biology 13. Autophagy-Lysosome-based therapies in neurological disorders 14. An update on clinical trials for autophagy-lysosome therapies in Parkinson's disease 15. Prospective targeting strategies and drug development Part 4: Neurobiological commonalities with other neurodegenerative proteinopathies 16.

The autophagy-lysosome pathway and overlaps with Alzheimer-like pathologies 17. The autophagy-lysosome pathway in other neurodegenerative diseases 18. Synaptic dysfunction in neurodegeneration 19. Towards a common pathophysiology scenario in neurodegenerative diseases?.