As research continues on the earliest migration of modern humans into North and South America, the current state of knowledge about these first Americans is continually evolving. Especially with recent advances in human genomic studies, both of living populations and ancient skeletal remains, new light is being shed in the ongoing quest toward understanding the full complexity and timing of prehistoric migration patterns. "Paleoamerican Odyssey" collects thirty-one studies presented at the 2013 conference by the same name, hosted in Santa Fe, New Mexico, by the Center for the Study of the First Americans at Texas A&M University. Providing an up-to-date view of the current state of knowledge in paleoamerican studies, the research gathered in this volume, presented by leaders in the field, focuses especially on late Pleistocene Northeast Asia, Beringia, and North and South America, as well as dispersal routes, molecular genetics, and Clovis and pre-Clovis archaeology.