The prevalence of overweight and obesity has increased exponentially during the past 30 years all around the world and now it is considered a global pandemic. Obesity is a multifactorial condition, caused by a complex interaction between biological, social and psychological factors. Most of the obesity treatments resulted to be ineffective, particularly those based on restrictive diets, which do not affect a long term weight loss and can contribute to higher psychological distress. However, interventions based on mindful eating, a not-judgemental awareness of physical and emotional sensations related to the experience of eating seem to be effective in reducing dysfunctional eating behaviors and in promoting physical and psychological well-being.