This book gathers peer-reviewed contributions to the 13th International Conference on E-Health and Bioengineering (EHB 2025), held in hybrid format on November 13&14, 2025, in/from IaÈi, Romania. They report on advances in medical devices and instrumentation, for a wide range of applications including medical diagnosis, therapy, and rehabilitation. They also describe the use of artificial intelligence in medicine for detecting and modeling diseases, health monitoring, medical decision making, and related applications. First volume of a three-volume set this book offers extensive and timely information to researchers and professionals in bioengineering, health informatics, and related interdisciplinary fields.