In this issue of Heart Failure Clinics , guest editor Dr. Kevin S. Shah brings his considerable expertise to the topic of Patient Selection, Referral Timing, and Advanced Heart Disease Therapy Options . Patient selection and timely referral are critical factors in managing advanced heart disease and ensuring patients receive optimal therapy. This issue addresses strategic assessment of patient health status, comorbidities, and disease progression, in order to make informed decisions about when and how to implement advanced heart disease therapies-potentially extending life expectancy and enhancing quality of life for high-risk patients. Contains 8 relevant, practice-oriented topics including heart failure with reduced EF; hypertrophic cardiomyopathy; amyloid cardiomyopathy; severe ischemic heart disease; sex differences in advanced heart disease; cardiogenic shock; and more Provides in-depth clinical reviews on patient selection, referral timing, and advanced heart disease therapy options , offering actionable insights for clinical practice Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.