Contributors xi Preface xiii Abbreviations xv Part 1: General Hemostasis 1 Overview of normal hemostasis 3 Jovan P. Antovic, Maria Farm, and Charlotte Gran 2 Sampling instructions and preanalytical issues in hemostasis 6 Maria Farm and Charlotte Gran 3 Laboratory investigation 9 Jovan P. Antovic, Maria Farm, Charlotte Gran, Bianca Tesi, and Agneta Wikman Part 2: Bleeding Disorders 4 Clinical and laboratory investigation of increased bleeding tendency 37 Charlotte Gran and Maria Magnusson 5 Hemophilia 45 Margareta Holmström and Susanna Ranta 6 Von Willebrand disease 52 Tony Frisk and Margareta Holmström 7 Rare bleeding disorders including inherited platelet function defects 58 Cecilia Karlström and Maria Magnusson 8 Specific issues of hemostasis in children - focus on bleeding 65 Maria Farm and Susanna Ranta 9 Hereditary bleeding disorders and aging 71 Jovan P. Antovic, Roza Chaireti, and Joel Ohm 10 Paradigm change - new treatment for hereditary bleeding disorders 75 Maria Magnusson and Susanna Ranta 11 Acquired inhibitors of coagulation factors 81 Roza Chaireti, Margareta Holmström, and Cecilia Karlström 12 Critical bleeding in trauma and surgery 89 Andreas Andersson, Carl Magnus Wahlgren, and Agneta Wikman 13 Gastrointestinal bleeding 93 Maria Magnusson and Per Stål 14 Intracranial bleeding 96 Michael V. Mazya and Michael Nekludov 15 Obstetric massive bleeding 101 Maria Sennström 16 Bleedings associated with anticoagulant and antiplatelet treatment (including reversal of antithrombotic treatment) 103 Margareta Holmström and Joel Ohm Part 3: Thromboembolic Disorders Venous Thrombosis 17 Venous thromboembolism 111 Joel Ohm 18 Specific issues of hemostasis in children - focus on thrombosis 128 Tony Frisk 19 Thrombotic issues with artificial surfaces 135 Lars Mikael Broman and Moa Simonsson 20 Treatment and prevention of venous thromboembolism 142 Margareta Holmström and Joel Ohm 21 Prevention of cardioembolism in atrial fibrillation 153 Michael V. Mazya and Moa Simonsson 22 Laboratory investigation of anticoagulant treatment 157 Jovan P. Antovic and Maria Farm 23 Ischemic heart disease 163 Moa Simonsson 24 Ischemic stroke and transient ischemic attack (TIA) 168 Michael V. Mazya 25 Peripheral artery disease 173 Carl Magnus Wahlgren 26 Antiplatelet treatment 176 Michael V.
Mazya and Moa Simonsson 27 Laboratory investigation of antiplatelet treatment 178 Charlotte Gran and Moa Simonsson Part 4: Special Hemostasis 28 Hemostasis in rheumatological and systemic disease 183 Aleksandra Antovic and Francesca Faustini 29 Hemostasis in COVID- 19 189 Maria Magnusson and Anna Sjöström 30 Hemostasis in liver disease 192 Maria Magnusson and Per Stål 31 Hemostasis in kidney disease 195 Peter Bárány and Maria Magnusson 32 Hemostasis in obstetrics and gynecology 199 Roza Chaireti and Maria Sennström 33 Hemostasis in cancer 219 Roza Chaireti, Tony Frisk, Charlotte Gran, and Susanna Ranta 34 Emergency conditions associated with hemostatic abnormalities 224 Jovan P. Antovic, Margareta Holmström, and Cecilia Karlström Index 230.