This book provides a comprehensive overview of diabetic wounds, highlighting the dual challenge of impaired wound healing and antimicrobial resistance. It explores pathophysiology, microbial biofilms, treatment limitations, and emerging therapeutic strategies including nanotechnology, peptides, natural products, and computational approaches. Special attention is given to the increasing prevalence of multidrug-resistant organisms in diabetic wound infections, which severely compromises patient outcomes and limits the effectiveness of conventional antibiotics. By addressing both biological and clinical aspects, the volume emphasizes the urgent need for integrated approaches to diagnosis, prevention, and treatment. Furthermore, the book critically examines existing therapeutic interventions, discusses their limitations in the context of resistant pathogens, and proposes innovative multidisciplinary strategies. With chapters contributed by experts from pharmacology, microbiology, nanotechnology, and clinical sciences, this book bridges the gap between fundamental research and translational applications in diabetic wound management. It will not only serve as a valuable resource for researchers and clinicians but also as a guide for graduate students and industry professionals seeking to understand the complexities of managing infections in diabetic wounds.