In this issue of Gastrointestinal Endoscopy Clinics of North America, guest editor Dr. Aasma Shaukat brings her considerable expertise to the topic of Colorectal Cancer Screening. Top experts provide a comprehensive exploration of evolving CRC risk factors, the latest advancements in non-invasive screening, the role of high-quality colonoscopy in detection and prevention, novel blood-based tests, and the use of AI assistance to improve patient outcomes in this rapidly evolving landscape. Contains 12 relevant, practice-oriented topics including risk factors for colorectal cancer, including early onset; screening for colorectal cancer with colonoscopy; interventions to improve quality of colonoscopy; effective polypectomy practices; improving adherence to colorectal cancer screening among underserved; and more. Provides in-depth clinical reviews on colorectal cancer screening, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.