1. Introduction 2. Georges Gilles de la Tourette in the history of tics Section 1. Clinical Diagnosis of Tics 3. Clinical presentation of tics and Gilles de la Tourette syndrome 4. Secondary Tics: Etiology, presentation and management 5. Functional tics and tic-like behaviors 6. Repetitive and restricted behaviors, habits, body-focused repetitive behaviors and motor stereotypies Section 2.

Comorbidities in Primary Tic Disorders 7. OCD in primary tic disorders and Tourette syndrome 8. Attention-deficit/hyperactivity disorder in primary tic disorders and Tourette Syndrome 9. Explosive outbursts and Tourette Syndrome/Chronic tic disorder 10. Sleep in tic disorders and Tourette Syndrome 11. Autism spectrum and other neurodevelopmental disorders 12. Sexuality and sexual health in primary tic disorders Section 3. Etiology and Pathophysiology 13.

Epidemiology of Tourette Syndrome 14. Genetics of tic disorders and Tourette Syndrome 15. Neuroimmunology of tics and Gilles de la Tourette syndrome 16. Animal models of Gilles de la Tourette syndrome and other tic disorders 17. Clinical neurophysiology of tics 18. Neuroimaging of tic disorders 19. Dopamine and other neurotransmitters 20. Premonitory urges and other sensory phenomena in primary tic disorders 21.

Inhibitory control and voluntary tic suppression Section 4. Treatments 22. Behavioral treatments of tic disorders 23. Pharmacological treatments 24. Deep brain stimulation for Gilles de la Tourette syndrome 25. Non-invasive brain stimulation for Gilles de la Tourette syndrome 26. Treatment of neuropsychiatric comorbidities in tic disorders Section 5. Overview of patient organizations and other useful resources 27.

Overview of support associations and other useful resources Section 6. Closing Remarks and Future 28. Closing remarks and future scope of unmet needs.