1. Introduction. Epigenetic mechanisms in brain function. 2. Evolution of epigenetic landscapes during pre and postnatal brain development and aging. 3. The role of DNA methylation and stepwise oxidation of 5 methylcytosine in epigenetic regulation of gene expression in the brain. 4.

Learning and memory. 5. Stress and the HPA axis 6. Metabolic homeostasis 7. Puberty and sexual behavior 8. Body Temperature and thermal regulation 9. The role of epigenetic mechanism in the neuroimmune axis 10. The impact of genetic alterations in epigenetic proteins on brain disorders.

11. Epigenetic processes in neurodevelopmental disorders (RETT syndrome, Autism) 12. Linking early adversity epigenetics and neuropsychiatric disorders (psychosis) 13. Epigenetic processes in substance abuse, and behavioral addictions 14. Epigenetic processes in neurological diseases Alzheimer, Parkinson disease, Parkinson, ALS 15. Epigenetic mechanisms in chronic pain 16. Early life adversity trauma and PTSD linked by epigenetic mechanisms 17. Epigenetic mechanisms in brain aging, cognitive decline and dementia 18.

Methodological challenges in epigenome wide associations with neuropsychiatry and behavioraldisorders 19. Animal models with construct validity for studying epigenetic processes in neurobehavior 20. Using epigenetic editing and to examine the role of site specific DNA methylation and oxidationalterations in neuroepigenetics. 21. Methods for dissecting cell neuron/glia/astrocyte specific patterns of methylationIPSC stem cells derived neuronal precursor cells to model in vitro the role of DNA methylation in the nervous system and brain disorders.