In this issue of Clinics in Laboratory Medicine , guest editor Dr. Jay Hudgins brings his considerable expertise to the topic of Emerging Considerations in Transfusion Medicine . Top experts explain the new schema by which donors are screened for patients with an overview of the supportive data, challenges of the shrinking donor pool, and what is being done to address this looming shortfall. This issue also provides an overview of all current apheresis procedures, discusses gene therapy products for sickle cell and thalassemia, and offers a look toward the future, including the RMAT program, application of AI in blood donation surveillance, distribution, immunohematology assessment, and in-hospital utilization. Contains 10 relevant, practice-oriented topics including implementation of the Individual Risk Assessment and changes to deferral periods since 2020; an overview of common apheresis procedures; AI application utilization in blood collection and immunohematology; disaster preparedness: strategies to for blood supply stewardship; and more Provides in-depth clinical reviews on emerging considerations in transfusion medicine , offering actionable insights for clinical practice Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.