Introduction and Principles 1 Historical Perspective 2 Anthrax: Ancient Surge and Current Biothreat 3 Tularemia: A bioterrorist threat and public health concern 4 Plague: the Yersinia pestis infection 5 VHF 6 Small pox 7 Preparing for Influenza epidemics and pandemics 8 Avian Influenza 9 SARS 10 MERS-CoV 11 SARS-CoV-2 ** New Chapter** 12 Designer pathogens and synthetic biology 13 Planning for a Bioterrorism or Pandemic Event: Public Health Perspective 14 Surveillance strategies 15 Prevention 16 Ethical issues in preparing for and responding to infectious outbreaks and bioterror attacks 17 Diagnostics 18 Transmission dynamics, modeling of outbreaks and interventions 19 Prophylaxis and Treatment **New Chapter** 20 Vaccines ** New Chapter** Appendix 21 Recovery from Biological Disasters 21 Communication strategies and the media 22 Communication strategies and the media ** New Chapter** 23 Pre-hospital care of patients with high impact pathogens 23 Media **New Chapter** 24 Translating Policy into Practice 25 Transmission based precautions and infection Prevention 26 Special Care Units.