The Joint Royal Colleges Ambulance Liaison Committee Clinical Guidelines are the essential clinical guideline resource for paramedics. The guidelines are written specifically for ambulance service' paramedics, combining evidence-based practice with expert advice and practical guidance. They provide a comprehensive overview of the many clinical conditions paramedics care for, and support them in providing excellent patient care. This 2025 edition has been updated with the latest evidence and developments in clinical practice. Key reviews have taken place on guidelines within the Maternity section, as well as updates to Medical guidelines such as Seizures in Adults and Children, and Pain Management. Medicine guidelines have been removed, but are available on the iCPG and JRCALC Plus apps, where they are regularly updated to ensure that the most up-to-date guidance is available to clinicians when providing direct patient care. The JRCALC Clinical Guidelines 2025 now contains crucial guidance on topics, including: Behavioural Emergencies Clinical Considerations in Relation to Diversity and Equality Conditions Requiring Specific Prehospital Clinical Management Drowning Overdose and Poisoning Seizures.