Preface xv 1 Natural Products for the Treatment of Testicular Cancer 1 Harpreet Singh, Himanshu Sharma, Rashmi Pathak, Amit Anand, Arvind Kumar, Amrita Mishra and Arun Kumar Mishra 1.1 Introduction 2 1.2 Promising Natural Products for Testicular Cancer 3 1.3 Mechanisms of Action of Natural Products in Testicular Cancer 15 1.4 Preclinical Studies and In Vitro Evidence 20 1.5 Clinical Trials and Human Studies 23 1.6 Role of Natural Products in Testicular Cancer 25 1.7 Future Prospects 29 1.
8 Conclusion 29 2 Natural Products for the Treatment of Male Sexual Dysfunction 39 Subhiksha. S., Akash. J., B. Siva Kumar and K. Ilango 2.1 Introduction 40 2.
2 Male Reproductive System 41 2.3 The Physiological Process of Achieving an Erection 42 2.4 Natural Substances that can Enhance Sexual Desire and Performance 43 2.5 Prospects for the Future 53 2.6 Conclusion 53 3 Phytochemicals as Potential Inhibitors of Phosphodiesterase-5 for Management of Erectile Dysfunction 61 Anand Ganapathy A., Vijayakumari Mahadevan Hari Priya, Raman Krishnamoorthi and Alaganandam Kumaran 3.1 Introduction 62 3.2 Causes of ED 64 3.
3 Diagnosis of ED 66 3.4 Treatments for ED 68 3.5 PDE5 and ED 72 3.6 Phytochemicals as PDE5 Inhibitors 79 3.7 Conclusion 90 4 Holistic Approaches to Benign Prostatic Hyperplasia: A Focus on Natural Therapies 99 Bharat Goel, Shivani Jaiswal and Tarkeshwar Dubey 4.1 Introduction 100 4.2 Natural Products in Benign Prostatic Hyperplasia (BPH) 102 4.3 Plants Used in Benign Prostate Hyperplasia (BPH) 112 4.
3.1 Saw Palmetto (S. repens, Sabal serrulata) 112 4.4 Conclusions 119 5 Unlocking Natural Arsenal for Prostate Cancer Care: From Garden to Clinic 125 Swati Arora, Sumit Sheoran, Samson Raj, Bhuvanesh Baniya, Neeraj Kumar, Anupam Kumar and Himanshu Singh 5.1 Introduction 126 5.2 Background of Prostate Cancer 126 5.3 Prostate Cancer: Main Risk Factors 128 5.4 Therapeutic Strategies: A Brief Summary 131 5.
5 Natural Arsenal and Prostate Cancer 136 5.6 Phytochemicals in Clinical Trials Against Prostate Cancer 139 5.7 Future Directions and Conclusion 141 6 Herbs as Antiandrogenic Agents 151 Pushpendra Kumar Khangar, Mayank Pandey, Nazneen Dubey and Aditya Ganeshpurkar 6.1 Introduction to Male Antifertility Agents 152 6.2 Mechanisms of Action 156 6.3 Plant-Derived Antiandrogenic Compounds 159 6.4 Pharmacological Studies and Clinical Trials 163 6.5 Commonly Studied Plant Species 166 6.
6 Formulation and Delivery Methods 168 6.7 Regulatory Considerations 169 6.8 Potential Applications in Male Contraception 171 6.9 Safety and Side Effects 173 6.10 Future Directions in Research 175 6.11 Targeted Drug Delivery Systems 178Contents ix 6.12 Challenges and Future Directions 180 6.13 Conclusion and Implications 181 7 Herbal Medicine for Prostatitis: A Current Approach 191 Satish Dubey, Harsh Yadav, Kundan Kumar Ojha, Shilpa Vinodia, Nagendra Singh Chauhan, Archana Markam, Sarita Chandrawanshi and Ashwini Kumar Dixit 7.
1 Introduction 192 7.2 Pathophysiology of Prostatitis 193 7.3 Conventional Management of Prostatitis 195 7.4 Antibiotics 195 7.5 Alpha Blockers 196 7.6 Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) 196 7.7 Role of Herbal Medicine in Prostatitis Management 197 7.8 escription of Some Key Medicinal Plants for Prostatitis 203 7.
9 Challenges and Future Outlook 205 7.10 Conclusion 206 8 Natural Products Used in Male Pattern Baldness 213 Rishu Kumar, Gracy Nath, Gireesh Kumar Singh, Debapriya Garabadu, Narahari Narayan Palei, Priyanka Sharma and Bibhash Chandra Mohanta 8.1 Introduction 214 8.2 Forms of Baldness and Types of Male Pattern Baldness 215 8.3 Causes of Baldness and Molecular Mechanism 217 8.4 Treatment Approaches of Male Pattern Baldness 219 8.5 Natural Products in Male Pattern Baldness 222 8.6 Future Perspective 230 8.
7 Conclusion 231 9 Role of Plants and Herbal Products to Manage Male Fertility 237 Pratap Chand Mali, Prity Yadav, Neha Bharti and Suman Kumari 9.1 Introduction 238 9.2 Review of Literature 239 9.3 Discussion 252 9.4 Future Prospects 252 9.5 Acknowledgements 252 10 Plants Used as Androgenic 259 Neetu Kachhwaha 10.1 Introduction 260 10.2 Androgens and Phytoandrogens 265 10.
3 Plants Having Androgenic Properties and Associated Diseases 270 10.4 Mode of Action 277Contents xi 10.5 Side Effects of Phytoandrogens 279 10.6 Plant-Derived Anti-Androgens 281 10.7 Future Perspective 281 11 Natural Products Used in Parkinson''s Disease 289 Manish Kumar, Vipasha Mehta, Ankita Rangra and Shreya Chauhan 11.1 Introduction 290 11.2 Epidemiology 291 11.3 Causes of Parkinson''s Disease 292 11.
4 Symptoms of PD 294 11.5 Natural Product Used in PD 297 11.6 Conclusion 310 12 Stress Induced Male Infertility: Propitious Role of Herbal Drugs 319 Jai Malik, Komal Tyagi and Prachi Pranamya 12.1 Introduction 320 12.2 Various Causes of Male Infertility 321 12.3 Some Common Plants Used to Treat Male Infertility 325 12.4 Conclusion 339 13 Natural Products as Spermatogenesis 351 Abhishek Mohanta, Sonalinandini Samanta, Sohini Chatterjee, Mousumi Tudu, Ahana Hazra, Arnab De and Amalesh Samanta 13.1 Introduction 352 13.
2 Current Scenario 353 13.3 Lifestyle Effects on Spermatogenesis 354 13.4 Natural Plants Used in Spermatogenesis 357 13.5 Plants that Affect Sertoli Cells 369 13.6 Future Perspective 372 13.7 Conclusion 372 14 Potential Role of Fructans in Male Cancers 385 Javad Arabpour 14.1 Introduction 386 14.2 Chemical Aspect of Fructan and Derivatives 388 14.
3 Bioactivity of Fructan 389 14.4 Pharmaceutical Application of Fructans 392 14.5 Fructans and Prostate Cancer 396 14.6 IV. Fructans and Other Male Cancers 397xiv Contents 14.7 Clinical Trials 398 14.8 Conclusions and Future Perspectives 403 References 404 Index 417.