In this issue of Heart Failure Clinics, guest editor Dr. Rodolfo Citro brings his considerable expertise to the topic of Heart and Brain: A Complex Interaction. Understanding the heart-brain relationship is crucial for managing conditions affecting both organs, leading to innovative diagnostic and therapeutic strategies for improved patient outcomes. In this issue, top experts discuss the heart-brain anatomical and physiological relationship; neurogenic cardiac syndromes; neurohumoral axis and stress cardiomyopathy; structural and functional brain features in Takotsubo syndrome; psychological stress and coronary artery syndromes; and more. Contains 13 relevant, practice-oriented topics including atrial myopathy and ESUS: a dangerous liaison?; Fabry disease: cardiac and neurological involvement; amyloidosis: cardiac and neurological involvement; atrial fibrillation and dementia: is there a link?; and more. Provides in-depth clinical reviews on heart and brain: a complex interaction, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.