Part I: Structural and Molecular Bases of Ion Channel Function 1. Voltage-Gated Sodium Channels and Electrical Excitability of the Heart 2. Voltage-Gated Calcium Channels 3. Voltage-Gated Potassium Channels 4. Molecular Regulation of Cardiac Inward Rectifier Potassium Channel 5. Mammalian Calcium Pumps in Health and Disease 6. Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function 7. Organellar Ion Channels and Transporters 8.
Molecular Organization, Gating, and Function of Connexin-Based Gap Junction Channels and Hemichannels Part II: Biophysics of Cardiac Ion Channel Function 9. Voltage-Gated Sodium Channels with Open and Closed Gates: Implications for State-Dependent Drug Design 10. Regulation of Cardiac Calcium Channels 11. Molecular Genetics of ATP-Sensitive K+ Channels in Cardiovascular Diseases 12. Role of Enhancers in Transcriptional Regulation of Cardiac Electrical Activity 13. Notch-Mediated Transcriptional and Epigenetic Regulation of Cardiac Ion Channels 14. Stretch-Activated Potassium Channels in the Human Heart: Pathophysiologic and Clinical Significance 15. Connexins and Pannexins in Cardiovascular Disease 16.
Excitation-Contraction Coupling Part III: Intermolecular Interactions and Cardiomyocyte Electrical Function 17. Ion Channel Trafficking in the Heart 18. Microdomain Interactions of Macromolecular Complexes and Regulation of the Sodium Channel Nav1.5 19. Connecting Cardiac Excitation to the Atomic Interactions of Ion Channels 20. Macromolecular Complexes and Cardiac Potassium Channels 21. Reciprocity of Cardiac Sodium and Potassium Channels in the Control of Excitability and Arrhythmias 22. The Intercalated Disc: A Molecular Network That Integrates Electrical Coupling, Intercellular Adhesion and Cell Excitability 23.
Function and Dysfunction of Ion Channel Membrane Trafficking and Post Translational Modification 24. Feedback Mechanisms for Cardiac-Specific microRNAs and cAMP Signaling in Electrical Remodeling Part IV: Cell Biology of Cardiac Impulse Initiation and Propagation 25. Coupled Oscillators and Sinoatrial Pacemaker Activity 26. Optical Mapping of Cardiac Action Potentials in Zebrafish to Assess Genetic Variants 27. Cell-to-Cell Communication and Impulse Propagation 28. Mechanisms of Normal and Dysfunctional Sinoatrial Nodal Excitability and Propagation 29. Cell Biology of the Specialized Cardiac Conduction System Part V: Models of Cardiac Excitation 30. Prediction of Drug-Induced Arrhythmia Using Machine Learning 31.
Global Optimization Approaches to Generate Dynamically Robust Electrophysiological Models 32. Calcium Signaling in Cardiomyocyte Models with Realistic Geometries 33. Theory of Rotors and Arrhythmias 34. Distinct ECG Phenotypes Identified in Hypertrophic Cardiomyopathy Using Machine Learning Associate With Arrhythmic Risk Markers 35. Computational Approaches for Accurate Rotor localization in the Human Atria 36. Modeling the Aging Heart 37. Electromechanical Vortex Filaments During Cardiac Fibrillation Part VI: Neural Control of Cardiac Electrical Activity 38. Innervation of the Sinoatrial Node 39.
Mechanisms for Altered Autonomic and Oxidant Regulation of Cardiac Sodium Currents 40. Neural Activity and Atrial Tachyarrhythmias 41. Sympathetic Modulation of Cardiac Electrophysiology 42. Role of the Autonomic Nervous System in Atrial Fibrillation Part VII: Arrhythmia Mechanisms 43. Rotors in Human Atrial Fibrillation 44. Nonivasive Frequency-Phase Mapping of Atrial Fibrillation 45. Electrical Biomarkers of the Progression of Atrial Fibrillation 46. Mechanisms of Human Ventricular Tachycardia and Human Ventricular Fibrillation 47.
Genetics of Atrial Fibrillation Part VIII: Molecular Genetics and Pharmacogenomics 48. Mechanisms in Heritable Sodium Channel Diseases 49. Genetic, Ionic and Cellular Mechanisms Underlying the J Wave Syndromes 50. Inheritable Potassium Channel Diseases 51. Inheritable Phenotypes Associated With Altered Intracellular Calcium Regulation Part IX: Pharmacologic, Genetic, and Cell Therapy of Ion Channel Dysfunction 52. Upstream therapy to prevent AF progression 53. Pharmacogenomics of Cardiac Arrhythmias 54. Screening Drugs for Myocardial Disease in Vivo with Zebrafish 55.
Gene Therapy for Atrial Fibrillation Part X: Cell biology and electrophysiology of human induced pluripotent stem cell derived cardiomyocytes 56. Cardiac Remodeling and Regeneration 57. High-Throughput Optical Mapping of 2 and 3-Dimensional hiPSC-CM Platforms for Drug Discovery and Cardiotoxicity Testing 58. Functional Cardiac Fibroblasts Derived from Human Pluripotent Stem Cells via Second Heart Field Progenitors 59. Functional Co-Culture of Sympathetic Neurons and Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells Part XI: Diagnostic Evaluation 60. Assessment of the Patient With a Cardiac Arrhythmia 61. Differential Diagnosis of Narrow and Wide Complex Tachycardias 62. Electrocardiographic Monitoring: Short, Long-Term Recording 63.
Personal Cardiac Monitoring 64. Computed Tomography for Electrophysiology 65. Magnetic Resonance Imaging for Electrophysiology 66. Intracardiac Echocardiography for Electrophysiology 67. Autonomic Nervous System Assessment for Syncope and Arrhythmia Risk 68. Non-invasive Electrocardiographic Imaging of Arrhythmogenic Substrates and Arrhythmias 69. Genetic Testing Part XII: Supraventricular Arrhythmias: Diagnosis and Therapy 70. Supraventricular Tachycardias: Diagnostic Maneuvers in the Electrophysiology Laboratory 71.
Atrial Tachycardia 72. Atrioventricular Nodal Reentrant Tachycardia 73. Junctional Tachycardia 74. Preexcitation, Atrioventricular Reentry, Variants 75. Atrial Fibrillation: Mechanisms, Clinical Features, and Management 76. Ablation for Atrial Fibrillation 77. Left Atrial Appendage Management 78. Typical and Atypical Atrial Flutter: Mapping and Ablation Part XIII: Ventricular Arrhythmias 79.
Sudden Cardiac Death in Adults 80. Premature Ventricular Complexes 81. Outflow Tract Ventricular Tachyarrhythmias: Mechanisms, Clinical Features, and Management 82. PVC Ablation with Anatomic Guidance: Papillary Muscle, Moderator Band and Valve Annulus Sites 83. Fascicular Ventricular Arrhythmias 84. Bundle Branch Reentry Tachycardia 85. Ventricular Arrhythmias in Ischemic Heart Disease 86. Ablation of Post-Myocardial Infarction VT 87.
Ventricular Tachycardia in Patients with Dilated Cardiomyopathy 88. Lamin A/C, Noncompaction and Other Genetic Cardiomyopathies with Ventricular Arrhythmias 89. Ventricular Arrhythmias in Hypertrophic Cardiomyopathy: Sudden Death, Risk Stratification, and Prevention With Implantable Defibrillators 90. Ventricular Tachycardias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy 91. Catecholaminergic Polymorphic Ventricular Tachycardia 92. Arrhythmias and Conduction Disturbances in Noncompaction Cardiomyopathy 93. Ventricular Arrhythmias in Takotsubo Cardiomyopathy 94. Mitral Valve Prolapse, ventricular arrhythmias and Sudden Death 95.
Brugada Syndrome 96. Long and Short QT Syndromes 97. Andersen-Tawil Syndrome 98. Timothy Syndrome 99. J-Wave Syndromes 100. Idiopathic Ventricular Fibrillation 101. Mapping and Ablation of Ventricular Fibrillation 102. Drug-Induced Ventricular Arrhythmias Part XIV: Syncope and Bradyarrhythmias 103.
Syncope 104. Sinus Node Abnormalities 105. Postural Orthostatic Tachycardia Syndrome 106. Atrioventricular Block Part XV: Arrhythmias in Special Populations 107. Sex Differences in Arrhythmias 108. Sudden Cardiac Deaths in Athletes, Including Commotio Cordis 109. Cardiac Sarcoidosis 110. Sleep-Disordered Breathing and Arrhythmias 111.
Ventricular Assist Devices and Cardiac Transplantation Recipients 112. Arrhythmia in Neurologic Disease 113. Cancer Therapy Related Arrhythmias Part XVI: Congenital Heart Disease and Pediatrics 114. Arrhythmias in the Pediatric Population 115. Supraventricular Tachycardias in Congenital Heart Disease 116. Ventricular Arrhythmias in Congenital Heart Disease Part XVII: Pharmacologic Therapy 117. Antiarrhythmic Drugs 118. Impact of Nontraditional Antiarrhythmic Drugs on Sudden Cardiac Death 119.
Oral Anticoagulants Part XVIII: Devices for Arrhythmia Management 120. Implantable Pacemakers 121. Implantable Cardioverter Defibrillators: Technical Aspects 122. Implantable Cardioverter Defibrillators: Clinical Aspects 123. Subcutaneous Implantable Cardioverter Defibrillators 124. Wearable Defibrillators 125. Cardiac Resynchronization Therapy 126. Management of Implanted Device Infections Part XIX: Catheter and Surgical Mapping and Ablation 127.
Electrogram Recording and Signal Processing 128. Electroanatomic Mapping for Arrhythmias 129. Mapping Scar-Related Arrhythmias 130. Radiofrequency Ablation 131. Cryoablation and Other Radiofrequency Alternatives 132. Transvascular Ethanol Ablation